Descriptors Found: 1
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 1 / 1 DeCS     
Descriptor English:   Complement Factor I 
Descriptor Spanish:   Factor I de Complemento 
Descriptor Portuguese:   Fator I do Complemento 
Synonyms English:   C3b C4b Inactivator
C3b Inactivator
C3b-C4b Inactivator
C4b C3b INA
C4b-C3b Inactivator, Complement
Complement 3b Complement 4b Inactivator
Complement 3b-Complement 4b Inactivator
Complement C4b C3b Inactivator
Complement C4b-C3b Inactivator
Inactivator, C3b
Inactivator, C3b-C4b
Inactivator, Complement C4b-C3b  
Tree Number:   D08.811.277.656.300.760.210
Definition English:   A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator. 
Indexing Annotation English:   do not confuse with FACTOR I see FIBRINOGEN
Pharmacological Action:   Complement Inactivating Agents
History Note English:   93; was FACTOR I, C 3B INACTIVATOR (NM) 1983-92 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   30774 
Unique Identifier:   D017244 

Occurrence in VHL: