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MFN=57035
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DeCS
Descriptor
English
:
Discs Large Homolog 1 Protein
Descriptor
Spanish
:
Homólogo 1 de la Proteína Discs Large
Descriptor
Portuguese
:
Proteína 1 Homóloga a Discs-Large
Synonyms
English
:
Synapse Associated Protein 97
Synapse-Associated Protein 97
Tree Number:
D08.811.913.696.650.450.500
D12.644.360.024.287
D12.776.157.057.023
D12.776.476.024.325
D12.776.543.213
Definition
English
:
A signaling adaptor protein that contains three
PDZ DOMAINS
; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits
ion channels
, receptors, and signaling molecules to discrete
plasma
membrane regions of polarized cells in the
HEART ATRIA
MYOCARDIUM
. It functions in the assembly of
ADHERENS JUNCTIONS
and regulation of
CELL PROLIFERATION
; synaptogenesis,
LYMPHOCYTE ACTIVATION
; and controls expression of KV4
POTASSIUM CHANNELS
to regulate excitability of CARDIAC MYOCYTES.
History Note
English
:
2018
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
57035
Unique Identifier:
D000074288
Occurrence in VHL
:
Similar:
DeCS