Search on: UBIQUITIN 
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Descriptor English:   Ubiquitin 
Descriptor Spanish:   Ubiquitina 
Descriptor Portuguese:   Ubiquitina 
Synonyms English:   APF-1
ATP Dependent Proteolysis Factor 1
ATP-Dependent Proteolysis Factor 1
High Mobility Protein 20
Human Ubiquitin
Ubiquitin, Human  
Tree Number:   D12.776.947.500
Definition English:   A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell. 
Indexing Annotation English:   UBIQUITINS is also available
History Note English:   2002; use UBIQUITINS (1985-2001) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   36260 
Unique Identifier:   D025801 

Occurrence in VHL: