Search on: INSULIN 
Descriptors Found: 1
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Descriptor English:   Insulin 
Descriptor Spanish:   Insulina 
Descriptor Portuguese:   Insulina 
Synonyms English:   Chain, Insulin B
Insulin A Chain
Insulin B Chain
Insulin, Regular
Insulin, Sodium
Insulin, Soluble
Regular Insulin
Sodium Insulin
Soluble Insulin  
Tree Number:   D06.472.699.587.200.500.625
Definition English:   A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). 
Indexing Annotation English:   /blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available
Pharmacological Action:   Hypoglycemic Agents
Entry Combination - descr/qualif English:   Insulin/antagonists & inhibitors use Insulin Antagonists
See Related English:   Hyperinsulinism
Nonsuppressible Insulin-Like Activity
Receptor, Insulin
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   7500 
Unique Identifier:   D007328 

Occurrence in VHL: