Search on: FACTOR XIIA 
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Descriptor English:   Factor XIIa 
Descriptor Spanish:   Factor XIIa 
Descriptor Portuguese:   Fator XIIa 
Synonyms English:   Activated Factor XII
Activator, Prekallikrein
Blood Coagulation Factor XII, Activated
Coagulation Factor XIIa
Factor 12A
Factor Twelve A
Factor XII, Activated
Factor XIIa, Coagulation
Fragments, Hageman-Factor
Hageman Factor Fragments
Hageman-Factor Fragments
Prekallikrein Activator  
Tree Number:   D08.811.277.656.300.760.324
Definition English:   Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII. 
Indexing Annotation English:   /defic = FACTOR XII DEFICIENCY
See Related English:   Coagulants
History Note English:   90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   24648 
Unique Identifier:   D015956 

Occurrence in VHL: