Descriptors Found: 1
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Descriptor English:   Cyclosporins 
Descriptor Spanish:   Ciclosporinas 
Descriptor Portuguese:   Ciclosporinas 
Synonyms English:   Cyclosporines  
Tree Number:   D04.345.566.235
Definition English:   A group of closely related cyclic undecapeptides from the fungi Trichoderma polysporum and Cylindocarpon lucidum. They have some antineoplastic and antifungal action and significant immunosuppressive effects. Cyclosporins have been proposed as adjuvants in tissue and organ transplantation to suppress graft rejection. 
Indexing Annotation English:   do not confuse with CYCLOSPORINE, a specific drug
Pharmacological Action:   Enzyme Inhibitors
Immunosuppressive Agents
History Note English:   82 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   3544 
Unique Identifier:   D003524 

Occurrence in VHL: