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DeCS
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Descriptor English:
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P-type ATPases
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Descriptor Spanish:
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ATPasas Tipo P
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Descriptor Portuguese:
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ATPases do Tipo-P
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Synonyms English:
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ATPases, E1-E2
ATPases, P-type
ATPases, Phosphorylation-type
Adenosine Triphosphatases, P-type
Adenosine Triphosphatases, Phosphorylation-type
E1 E2 ATPases
E1-E2 ATPases
P type ATPases
P type Adenosine Triphosphatases
P-type Adenosine Triphosphatases
Phosphorylation type ATPases
Phosphorylation type Adenosine Triphosphatases
Phosphorylation-type ATPases
Phosphorylation-type Adenosine Triphosphatases
Triphosphatases, P-type Adenosine
Triphosphatases, Phosphorylation-type Adenosine
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Tree Number:
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D08.811.277.040.025.314
D12.776.157.530.813
D12.776.543.585.813
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Definition English:
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A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane. |
History Note English:
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2018
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Allowable Qualifiers English:
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Record Number:
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56997
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Unique Identifier:
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D000073779
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Occurrence in VHL:
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Similar:
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DeCS
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