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CYTOCHROME P 450 CYP7
Descriptors Found:
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DeCS
Descriptor
English
:
Cholesterol 7-alpha-Hydroxylase
Descriptor
Spanish
:
Colesterol 7-alfa-Hidroxilasa
Descriptor
Portuguese
:
Colesterol 7-alfa-Hidroxilase
Synonyms
English
:
CYP 7
CYP 7A
CYP7
CYP7A
Cholesterol 7 Hydroxylase
Cholesterol 7 alpha Hydroxylase
Cholesterol 7 alpha Monooxygenase
Cholesterol 7-alpha-Monooxygenase
Cholesterol 7alpha Hydroxylase
Cholesterol 7alpha-Hydroxylase
Cholesterol-7-Hydroxylase
Cytochrome P 450 CYP7
Cytochrome P-450 CYP7
Cytochrome P450 7
Tree Number:
D08.244.453.890.500
D08.244.453.915.200
D08.811.682.690.708.170.890.500
D08.811.682.690.708.170.915.200
D12.776.422.220.453.890.500
D12.776.422.220.453.915.200
Definition
English
:
A membrane-bound
cytochrome
P450 enzyme that catalyzes the 7-alpha-hydroxylation of
CHOLESTEROL
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP7, converts
cholesterol
to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.
History Note
English
:
2003 (1975)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23193
Unique Identifier:
D002790
Occurrence in VHL
:
Similar:
DeCS