Search on:
C-PEPTIDE
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
C-Peptide
Descriptor
Spanish
:
Péptido C
Descriptor
Portuguese
:
Peptídeo C
Synonyms
English
:
C Peptide
C Peptide, Proinsulin
C-Peptide, Proinsulin
Connecting Peptide
Proinsulin C Peptide
Proinsulin C-Peptide
Tree Number:
D06.472.699.587.200.500.250
D12.644.548.586.200.500.250
Definition
English
:
The middle segment of
proinsulin
that is between the N-terminal B-chain and the C-terminal A-chain. It is a pancreatic peptide of about 31 residues, depending on the species. Upon proteolytic cleavage of
proinsulin
, equimolar
INSULIN
and
C-peptide
are released.
C-peptide
immunoassay
has been used to assess pancreatic beta cell function in diabetic
patients
with circulating
insulin antibodies
or exogenous
insulin
.
Half-life
of
C-peptide
is 30 min, almost 8 times that of
insulin.
Indexing Annotation
English
:
from
proinsulin
only: not for
peptide fragments
from other
proteins
( =
PEPTIDE FRAGMENTS
)
History Note
English
:
84(77); was see under PEPTIDES 1977-83
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
2130
Unique Identifier:
D002096
Occurrence in VHL
:
Similar:
DeCS