Descriptors Found: 1
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Descriptor English:   Transglutaminases 
Descriptor Spanish:   Transglutaminasas 
Descriptor Portuguese:   Transglutaminases 
Synonyms English:   Gamma-Glutamyltransferases, Glutaminyl-Peptide
Glutaminyl Peptide Gamma Glutamyltransferases
Glutaminyl-Peptide Gamma-Glutamyltransferases
Protein Glutamine gamma Glutamyltransferases
Protein-Glutamine gamma-Glutamyltransferases
gamma-Glutamyltransferases, Protein-Glutamine  
Tree Number:   D08.811.913.050.200.800
Definition English:   Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence. 
Indexing Annotation English:   distinguish X refs GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available
History Note English:   2002(1986) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   27787 
Unique Identifier:   D011503 

Occurrence in VHL: