Descriptors Found: 1
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Descriptor English:   Caspases, Initiator 
Descriptor Spanish:   Caspasas Iniciadoras 
Descriptor Portuguese:   Caspases Iniciadoras 
Synonyms English:   Initiator Caspases  
Tree Number:   D08.811.277.656.262.500.126.550
Definition English:   A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES. 
Entry Combination - descr/qualif English:   Caspases, Initiator/antagonists & inhibitors use Caspase Inhibitors
History Note English:   2007 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   52225 
Unique Identifier:   D053471 

Occurrence in VHL: