Search on: CASPASES 
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Descriptor English:   Caspases 
Descriptor Spanish:   Caspasas 
Descriptor Portuguese:   Caspases 
Tree Number:   D08.811.277.656.262.500.126
Definition English:   A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur. 
Indexing Annotation English:   CASPASES, EFFECTOR and CASPASES, INITIATOR and specifics are available
Entry Combination - descr/qualif English:   Caspases/antagonists & inhibitors use Caspase Inhibitors
See Related English:   Apoptosis
History Note English:   99 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   33826 
Unique Identifier:   D020169 

Occurrence in VHL: