Descriptors Found: 1
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Descriptor English:   Calcineurin 
Descriptor Spanish:   Calcineurina 
Descriptor Portuguese:   Calcineurina 
Synonyms English:   Calcineurin A
Calcineurin B
Phosphatase 3, Protein
Protein Phosphatase 2B
Protein Phosphatase 3
Protein Phosphatase 3 Catalytic Subunit
Protein Phosphatase 3 Regulatory Subunit
Protein Phosphatase-2B  
Tree Number:   D08.811.277.352.650.625.150
Definition English:   A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes. 
Entry Combination - descr/qualif English:   Calcineurin/antagonists & inhibitors use Calcineurin Inhibitors
History Note English:   98; see CALCINEURIN (NM) 1987-97 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   33429 
Unique Identifier:   D019703 

Occurrence in VHL: