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DeCS
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Descriptor English:
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Calcineurin
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Descriptor Spanish:
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Calcineurina
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Descriptor Portuguese:
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Calcineurina
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Synonyms English:
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Calcineurin A
Calcineurin B
Phosphatase 3, Protein
Protein Phosphatase 2B
Protein Phosphatase 3
Protein Phosphatase 3 Catalytic Subunit
Protein Phosphatase 3 Regulatory Subunit
Protein Phosphatase-2B
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Tree Number:
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D08.811.277.352.650.625.150
D12.644.360.087
D12.776.476.087
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Definition English:
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A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes. |
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Entry Combination - descr/qualif English:
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Calcineurin/antagonists & inhibitors use Calcineurin Inhibitors
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History Note English:
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98; see CALCINEURIN (NM) 1987-97
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Allowable Qualifiers English:
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Record Number:
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33429
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Unique Identifier:
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D019703
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Occurrence in VHL:
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Similar:
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DeCS
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