1 / 1
|
DeCS
|
|
|
Descriptor English:
|
|
DCC Receptor
|
Descriptor Spanish:
|
|
Receptor DCC
|
Descriptor Portuguese:
|
|
Receptor DCC
|
Synonyms English:
|
|
DCC Netrin 1 Receptor
DCC Tumor Suppressor Protein
DCC-Netrin-1 Receptor
Deleted in Colorectal Carcinoma Protein
Receptor, DCC
Receptor, DCC-Netrin-1
|
Tree Number:
|
|
D12.644.360.075.413
D12.776.476.075.413
D12.776.543.750.003.500
D12.776.624.776.021
|
Definition English:
|
|
A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells. |
History Note English:
|
|
2018
|
Allowable Qualifiers English:
|
|
|
Record Number:
|
|
57057
|
Unique Identifier:
|
|
D000075389
|
Occurrence in VHL:
|
|
|
Similar:
|
|
DeCS
|