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MFN=57004
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DeCS
Descriptor
English
:
MRE11 Homologue Protein
Descriptor
Spanish
:
Proteína Homóloga de MRE11
Descriptor
Portuguese
:
Proteína Homóloga a MRE11
Synonyms
English
:
Homologue Protein, MRE11
MRE11A Protein
Meiotic Recombination 11 Homolog 1 Protein
Tree Number:
D08.811.277.352.335.350.650
D08.811.277.352.335.375.813
D08.811.277.352.355.325.600
D08.811.277.352.365.290.250
D12.776.157.687.495
D12.776.260.539
D12.776.660.720.495
Definition
English
:
A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED
DNA BREAKS
;
RECOMBINATIONAL DNA REPAIR
;
maintenance
of
TELOMERE
integrity and
MEIOSIS
. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity.
Mutations
in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.
History Note
English
:
2018
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
57004
Unique Identifier:
D000076228
Occurrence in VHL
:
Similar:
DeCS