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ALPHA-SYNUCLEINOPATHY
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DeCS
Descriptor
English
:
Synucleinopathies
Descriptor
Spanish
:
Sinucleinopatías
Descriptor
Portuguese
:
Sinucleinopatias
Synonyms
English
:
Synucleinopathy
a-Synucleinopathies
a-Synucleinopathy
alpha Synuclein Pathologies
alpha Synuclein Pathology
alpha Synucleinopathies
alpha-Synucleinopathies
alpha-Synucleinopathy
Tree Number:
C10.574.928
C18.452.845.650
Definition
English
:
Neurodegenerative disorders involving deposition of abnormal
ALPHA-SYNUCLEIN
in
dopaminergic neurons
and glial cells in the brain. Pathological aggregations of
alpha-synuclein
proteins
results in
LEWY BODIES
and Lewy
neurites
; melanin granules in the
SUBSTANTIA NIGRA
and
LOCUS COERULEUS
; and glial cytoplasmic inclusions.
Synucleinopathies
are associated with
mutation
in the
ALPHA-SYNUCLEIN
(SNCA) gene on
chromosome 4
.
PARKINSON DISEASE
;
LEWY BODY DISEASE
with
dementia
; and
MULTIPLE SYSTEM ATROPHY
are prominent examples of synucleinopathy.
See Related
English
:
Lewy Bodies
alpha-Synuclein
History Note
English
:
2020
Allowable Qualifiers
English
:
BL
blood
CF
cerebrospinal fluid
CI
chemically induced
CL
classification
CO
complications
CN
congenital
DI
diagnosis
DG
diagnostic imaging
DH
diet therapy
DT
drug therapy
EC
economics
EM
embryology
EN
enzymology
EP
epidemiology
EH
ethnology
ET
etiology
GE
genetics
HI
history
IM
immunology
ME
metabolism
MI
microbiology
MO
mortality
NU
nursing
PS
parasitology
PA
pathology
PP
physiopathology
PC
prevention & control
PX
psychology
RT
radiotherapy
RH
rehabilitation
SU
surgery
TH
therapy
UR
urine
VE
veterinary
VI
virology
Record Number:
59254
Unique Identifier:
D000080874
Occurrence in VHL
:
Similar:
DeCS