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DeCS
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Descriptor English:
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Progranulins
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Descriptor Spanish:
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Progranulinas
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Descriptor Portuguese:
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Progranulinas
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Synonyms English:
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Acrogranin
Granulin Precursor
Granulin Precursor Protein
PC Cell Derived Growth Factor
PC Cell-Derived Growth Factor
Proepithelin
Progranulin
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Tree Number:
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D06.472.699.682
D12.644.276.917
D12.776.467.917
D12.776.811.703
D23.529.917
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Definition English:
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Cysteine-rich, precursor glycoproteins encoded by the granulin gene (GRN). They contain granulin-repeats separated by linker sequences that are cleaved by a variety of proteases to release the individual GRANULIN PEPTIDES. The mammalian progranulin is composed of a half-granulin repeat followed by 7 granulin repeats. The mammalian GRANULINS are named PARAGRANULIN and granulin 1-7 for their order in the progranulin propeptide. Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is linked to neurodegenerative diseases including FRONTOTEMPORAL DEMENTIA and NEURONAL CEROID LIPOFUSCINOSIS, while over-expression is linked to metabolic diseases including OBESITY, and INSULIN RESISTANCE. |
History Note English:
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2019
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Allowable Qualifiers English:
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Record Number:
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57523
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Unique Identifier:
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D000077153
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Occurrence in VHL:
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Similar:
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DeCS
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