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BUPRENEX
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DeCS
Descriptor
English
:
Buprenorphine
Descriptor
Spanish
:
Buprenorfina
Descriptor
Portuguese
:
Buprenorfina
Synonyms
English
:
6029 M
6029-M
6029M
Buprenex
Buprenorphine Hydrochloride
Buprex
Hydrochloride, Buprenorphine
Prefin
RX 6029 M
RX-6029-M
RX6029M
Subutex
Temgesic
Temgésic
Tree Number:
D03.132.577.249.150
D03.605.497.150
D03.633.400.686.150
D04.615.723.795.150
Definition
English
:
A derivative of the opioid alkaloid
THEBAINE
that is a more potent and longer lasting analgesic than
MORPHINE
. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the
observation
that
buprenorphine
tolerance may not develop with chronic use.
Indexing Annotation
English
:
for
buprenorphine
maintenance
treatment, coordinate with
OPIATE SUBSTITUTION TREATMENT
Pharmacological Action:
Analgesics, Opioid
Narcotic Antagonists
Narcotics
See Related
English
:
Opiate Substitution Treatment
History Note
English
:
87(79); was see under MORPHINANS 1979-86
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
2079
Unique Identifier:
D002047
Occurrence in VHL
:
Similar:
DeCS