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DeCS
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Descriptor Inglés:
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Pyrin
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Descriptor Español:
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Pirina
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Descriptor Portugués:
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Pirina
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Sinónimos Inglés:
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MEFV Protein
Marenostrin
Mediterranean Fever Protein
TRIM20 Protein
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Categoría:
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D12.776.220.909
D12.776.934.750
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Definición Inglés:
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A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER. |
Relacionados Inglés:
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Pyrin Domain
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Nota Histórica Inglés:
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2017 (1997)
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Calificadores Permitidos Inglés:
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Número del Registro:
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56595
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Identificador Único:
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D000071198
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Ocurrencia en la BVS:
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Similar:
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DeCS
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