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DeCS
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Descriptor English:
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Kernicterus
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Descriptor Spanish:
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Kernicterus
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Descriptor Portuguese:
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Kernicterus
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Synonyms English:
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Bilirubin Encephalopathies
Bilirubin Encephalopathy
Encephalopathies, Bilirubin
Encephalopathies, Hyperbilirubinemic
Encephalopathy, Bilirubin
Encephalopathy, Hyperbilirubinemic
Hyperbilirubinemic Encephalopathies
Hyperbilirubinemic Encephalopathy
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Tree Number:
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C10.228.140.163.480
C15.378.295.502
C16.614.304.502
C18.452.132.480
C20.306.502
C23.550.429.750
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Definition English:
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A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613) |
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Allowable Qualifiers English:
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Record Number:
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7813
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Unique Identifier:
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D007647
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Occurrence in VHL:
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Similar:
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DeCS
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