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Descriptor English:   Chaperone-Mediated Autophagy 
Descriptor Spanish:   Autofagia Mediada por Chaperonas 
Descriptor Portuguese:   Autofagia Mediada por Chaperonas 
Synonyms English:   Autophagy, Chaperone-Mediated
Chaperone Mediated Autophagy  
Tree Number:   G04.011.625
Definition English:   A selective type of autophagy in which a specific set of cytosolic proteins are moved across the membrane of the LYSOSOMES by protein translocation, rather than by invagination of the lysosomal membrane. The proteins that will be degraded by chaperone-mediated autophagy (CMA) contain a CMA-targeting motif that, when exposed, is recognized by the cytosolic chaperone HSPA8 (aka Hsc70) and cochaperones which deliver the protein to LAMP2A monomers on the lysosome cell surface for translocation via the LAMP2A translocation complex. CMA is distinguished from CHAPERONE-ASSISTED-SELECTIVE AUTOPHAGY - a type of selective MACROAUTOPHAGY. 
History Note English:   2020 
Allowable Qualifiers English:  
DE drug effects GE genetics
IM immunology PH physiology
RE radiation effects  
Record Number:   59051 
Unique Identifier:   D000080642 

Occurrence in VHL: