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PARAPROTEINS
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DeCS
Descriptor
English
:
Paraproteins
Descriptor
Spanish
:
Paraproteínas
Descriptor
Portuguese
:
Paraproteínas
Tree Number:
D12.776.124.486.485.900
D12.776.124.790.651.900
D12.776.377.715.548.900
Definition
English
:
Abnormal
immunoglobulins
synthesized by atypical cells of the
MONONUCLEAR PHAGOCYTE SYSTEM
.
Paraproteins
containing only light chains lead to Bence Jones paraproteinemia, while the presence of only atypical heavy chains leads to
heavy chain disease
. Most of the
paraproteins
show themselves as an M-component (monoclonal gammopathy) in
electrophoresis
. Diclonal and polyclonal
paraproteins
are much less frequently encountered.
Pharmacological Action:
Immunologic Factors
History Note
English
:
76; was see under GLOBULINS 1963-65
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22253
Unique Identifier:
D010266
Occurrence in VHL
:
Similar:
DeCS