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DeCS
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Descritor Inglês:
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PR-SET Domains
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Descritor Espanhol:
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Dominios PR-SET
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Descritor Português:
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Domínios PR-SET
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Sinônimos Inglês:
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Domain, PR
Domain, PR-SET
Domain, SET
Domains, PR
Domains, PR-SET
Domains, SET
PR Domain
PR Domains
PR SET Domains
PR-SET Domain
SET Domain
SET Domains
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Categoria:
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G02.111.570.820.709.275.750.477
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Definição Inglês:
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Highly conserved protein domains of approximately 130 to 140 amino acids. The SET domain was first identified in the Drosophila proteins (S)u(var)3-9, (E)nhancer-of-zeste and (T)rithorax and occurs in other proteins with a variety of functions, including histone-lysine N-methyltransferases. Structurally, it consists of BETA-SHEETS interspersed among loops and turns that result in an "L" shape. The most conserved motifs are a stretch at the C-terminal that contains a strictly conserved tyrosine residue and an adjacent loop that the C-terminal segment passes through to form a "knot". These motifs and especially the tyrosine residue are essential for S-ADENOSYLMETHIONINE binding and catalysis. The PR domain has high homology to the catalytic region of the SET domain and occurs at the N-terminal of PRDM proteins such as PRDM1 PROTEIN. |
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Nota Histórica Inglês:
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2018
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Qualificadores Permitidos Inglês:
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Número do Registro:
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57255
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Identificador Único:
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D000074463
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Ocorrência na BVS:
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Similar:
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DeCS
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