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MFN=57034
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DeCS
Descritor
Inglês
:
c-Mer Tyrosine Kinase
Descritor
Espanhol
:
Tirosina Quinasa c-Mer
Descritor
Português
:
c-Mer Tirosina Quinase
Sinônimos
Inglês
:
Kinase, c-Mer Tyrosine
MERTK
Tyrosine Kinase, c-Mer
c Mer Proto Oncogene Tyrosine Kinase
c Mer Tyrosine Kinase
c-Mer Proto-Oncogene Tyrosine Kinase
Categoria:
D08.811.913.696.620.682.725.400.003
D12.776.543.750.630.003
D12.776.624.664.700.037
Definição
Inglês
:
A receptor
tyrosine
kinase that transduces signals from
EXTRACELLULAR MATRIX
to the
CYTOPLASM
by binding
ligands
such as
GALECTIN 3
. It regulates many physiologic processes that include
cell survival
, migration, differentiation, and
PHAGOCYTOSIS
of apoptotic cells and ROD PHOTORECEPTORS in the
RETINAL PIGMENT EPITHELIUM
.
Mutations
in the MERTK gene are associated with type 38
RETINITIS PIGMENTOSA
; it also plays a critical role as an inhibitor of
TOLL-LIKE RECEPTORS
signaling.
Nota Histórica
Inglês
:
2018
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Número do Registro:
57034
Identificador Único:
D000076202
Ocorrência na BVS
:
Similar:
DeCS