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DeCS
Descritor
Inglês
:
High-Temperature Requirement A Serine Peptidase 1
Descritor
Espanhol
:
Serina Peptidasa A1 que Requiere Temperaturas Altas
Descritor
Português
:
Serina Peptidase 1 de Requerimento de Alta Temperatura A
Sinônimos
Inglês
:
HTRA1, Serine Protease
High Temperature Requirement A Serine Peptidase 1
Protease HTRA1, Serine
Serine Protease HTRA1
Categoria:
D08.811.277.656.300.760.420
D08.811.277.656.959.350.420
Definição
Inglês
:
A secreted
serine
protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include
EXTRACELLULAR MATRIX PROTEINS
;
PROTEOGLYCANS
; and
INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS
.
Mutations
in the HTRA1 gene are associated with AGE-RELATED
MACULAR DEGENERATION
7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).
Relacionados
Inglês
:
Kazal Motifs
PDZ Domains
Nota Histórica
Inglês
:
2018
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
57007
Identificador Único:
D000074289
Ocorrência na BVS
:
Similar:
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