Search on: MFN=8159 
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Descriptor English:   Lewis Blood Group Antigens 
Descriptor Spanish:   Antígenos del Grupo Sanguíneo de Lewis 
Descriptor Portuguese:   Antígenos do Grupo Sanguíneo de Lewis 
Synonyms English:   Antigens, Lewis
Antigens, Lewis Related
Antigens, Sialyl Lewis
Blood Group Lewis Related Antigens
Blood-Group System, Lewis
Le Antigens
Le(a) Blood Group System
Lewis Antigen Related Tumor Associated Antigens
Lewis Antigen Related Tumor-Associated Antigens
Lewis Antigens
Lewis Blood Group Related Antigens
Lewis Blood Group Related Tumor Associated Antigens
Lewis Blood Group Related Tumor-Associated Antigens
Lewis Blood Group System
Lewis Blood-Group System
Lewis Related Antigens
Lewis System
Sialyl Lewis Antigens  
Tree Number:   D23.050.301.290.544
D23.050.705.230.544
Definition English:   Carbohydrate antigens structurally related to the ABH BLOOD-GROUP SYSTEM. They may occur as a modification of saccharide chains on glycolipids or glycoproteins on cell surfaces or in plasma, or as free oligosaccharides in secretions. Lewis antigens are not synthesized in blood cells. Instead Lewis glycolipids present in plasma are absorbed onto the surface of ERYTHROCYTES; LYMPHOCYTES; and PLATELETS. The phenotypes Le(a) and Le(b) are the result of the actions of two genes the Le gene (fucosyltransferase FUT3) and the Se gene (fucosyltransferase FUT2) on the precursor carbohydrate, glycolipid or glycoprotein. Other FUCOSYLTRANSFERASES can also synthesize the Lewis antigens. 
Indexing Annotation English:   coordinate with disease /blood, not /immunol nor /genet
History Note English:   2020 (1963) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CH chemistry CL classification
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PD pharmacology PH physiology
PO poisoning TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   8159 
Unique Identifier:   D007983 

Occurrence in VHL:
 

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