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MFN=59044
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DeCS
Descriptor
English
:
Calicheamicins
Descriptor
Spanish
:
Calicheamicinas
Descriptor
Portuguese
:
Calicheamicinas
Synonyms
English
:
Calicheamicin
Tree Number:
D02.455.326.271.244.250
D02.455.326.397.680.500.500.250
D09.408.051.247
Definition
English
:
Enediyne
aminoglycosides
derived from the bacterium
MICROMONOSPORA ECHINOSPORA
that are used as antineoplastic antibiotics. They bind to DNA in both healthy and tumor cells, resulting in strand scission and
cell death.
Pharmacological Action:
Antibiotics, Antineoplastic
History Note
English
:
2020
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
59044
Unique Identifier:
D000080084
Occurrence in VHL
:
Similar:
DeCS