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TRIMETHOPRIM
Descriptors Found:
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DeCS
Descriptor
English
:
Trimethoprim
Descriptor
Spanish
:
Trimetoprim
Descriptor
Portuguese
:
Trimetoprima
Synonyms
English
:
Proloprim
Trimpex
Tree Number:
D03.383.742.906
Definition
English
:
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to
PYRIMETHAMINE
. It is potentiated by
SULFONAMIDES
and the
TRIMETHOPRIM
,
SULFAMETHOXAZOLE
DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial.
TRIMETHOPRIM RESISTANCE
has been reported.
Indexing Annotation
English
:
consider
TRIMETHOPRIM RESISTANCE
for nonsusceptibility of
bacteria
Pharmacological Action:
Anti-Infective Agents, Urinary
Antimalarials
Folic Acid Antagonists
Anti-Dyskinesia Agents
Cytochrome P-450 CYP2C8 Inhibitors
See Related
English
:
Trimethoprim Resistance
History Note
English
:
1974 (1972)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
14697
Unique Identifier:
D014295
Occurrence in VHL
:
Similar:
DeCS