Search on: TENIPOSIDE 
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Descriptor English:   Teniposide 
Descriptor Spanish:   Tenipósido 
Descriptor Portuguese:   Teniposídeo 
Synonyms English:   Demethyl Epipodophyllotoxin Thenylidine Glucoside
NSC 122819
NSC-122819
NSC122819
Teniposide, (5a alpha,9 alpha(S*))-Isomer
VM 26
VM-26
VM26
Vumon  
Tree Number:   D09.408.348.800
Definition English:   A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. 
Pharmacological Action:   Antineoplastic Agents
Topoisomerase II Inhibitors
 
History Note English:   91(81); was see under PODOPHYLLOTOXIN 1981-90; was VM 26 see under PODOPHYLLOTOXIN 1976-80 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   14091 
Unique Identifier:   D013713 

Occurrence in VHL:
 

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