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TLCK
Descriptors Found:
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DeCS
Descriptor
English
:
Tosyllysine Chloromethyl Ketone
Descriptor
Spanish
:
Clorometilcetona Tosilisina
Descriptor
Portuguese
:
Tosilina Clorometil Cetona
Synonyms
English
:
Chloromethane, Tosyllysyl
Chloromethyl Ketone, Tosyllysine
Chlorotosylamidoaminoheptanone
Ketone, Tosyllysine Chloromethyl
TLCK
Tosyllysyl Chloromethane
Tree Number:
D02.455.426.559.389.832.690
D02.886.590.887.600
D12.125.065.850
Definition
English
:
An inhibitor of
SERINE ENDOPEPTIDASES
. Acts as an alkylating agent and is known to interfere with the translation process.
Pharmacological Action:
Alkylating Agents
Protein Synthesis Inhibitors
Serine Proteinase Inhibitors
History Note
English
:
91(75); was see under AMINO ACID CHLOROMETHYL KETONES 1977-90; was see under LYSINE 1975-76
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
14499
Unique Identifier:
D014107
Occurrence in VHL
:
Similar:
DeCS