Search on: TIMP-2 
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Descriptor English:   Tissue Inhibitor of Metalloproteinase-2 
Descriptor Spanish:   Inhibidor Tisular de Metaloproteinasa-2 
Descriptor Portuguese:   Inibidor Tecidual de Metaloproteinase-2 
Synonyms English:   Metalloproteinase-2 Tissue Inhibitor
TIMP-2
Tissue Inhibitor of Metalloproteinase 2  
Tree Number:   D12.776.645.875.500
Definition English:   A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo. 
Pharmacological Action:   Matrix Metalloproteinase Inhibitors
 
History Note English:   1998; see TISSUE INHIBITOR OF METALLOPROTEINASE-2 (NM) 1989-1997 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   33427 
Unique Identifier:   D019716 

Occurrence in VHL:
 

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