Search on: TIMP-1 
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Descriptor English:   Tissue Inhibitor of Metalloproteinase-1 
Descriptor Spanish:   Inhibidor Tisular de Metaloproteinasa-1 
Descriptor Portuguese:   Inibidor Tecidual de Metaloproteinase-1 
Synonyms English:   Metalloproteinase-1 Tissue Inhibitor
TIMP-1
Tissue Inhibitor of Metalloproteinase 1  
Tree Number:   D12.776.645.875.450
Definition English:   A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro. 
Pharmacological Action:   Matrix Metalloproteinase Inhibitors
 
History Note English:   98; see TISSUE-INHIBITOR OF METALLOPROTEINASE-1 (NM) 1980-97 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   33426 
Unique Identifier:   D019715 

Occurrence in VHL:
 

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