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DeCS
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Descriptor English:
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Superantigens
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Descriptor Spanish:
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Superantígenos
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Descriptor Portuguese:
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Superantígenos
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Tree Number:
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D23.050.820
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Definition English:
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Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions. |
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Indexing Annotation English:
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coordinate IM with specific microbe /immunol (IM); for interaction of superantigens with endotoxins, coordinate with ENDOTOXINS or specifics
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See Related English:
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Apoptosis
Clonal Anergy
Receptors, Antigen, T-Cell, alpha-beta
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History Note English:
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94
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Allowable Qualifiers English:
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Record Number:
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31023
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Unique Identifier:
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D018089
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Occurrence in VHL:
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Similar:
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DeCS
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