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SIRTUINS
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DeCS
Descriptor
English
:
Sirtuins
Descriptor
Spanish
:
Sirtuinas
Descriptor
Portuguese
:
Sirtuínas
Synonyms
English
:
SIRTs
Silent Mating Type Information Regulator 2 like Proteins
Silent Mating Type Information Regulator 2-like Proteins
Sir2 like Proteins
Sir2-like Proteins
Tree Number:
D08.811.277.087.520.200.650
D08.811.913.400.725.115.961
D12.776.476.900
Definition
English
:
A homologous
family
of regulatory
enzymes
that are structurally related to the protein silent mating type
information
regulator 2 (Sir2) found in
Saccharomyces cerevisiae
.
Sirtuins
contain a central catalytic core region which binds NAD. Several of the
sirtuins
utilize NAD to deacetylate
proteins
such as
HISTONES
and are categorized as
GROUP III HISTONE DEACETYLASES
. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to
proteins
and are categorized as MONO ADP-RIBOSE
TRANSFERASES
, while a third group of
sirtuins
appears to have both deacetylase and ADP
ribose
transferase
activities.
See Related
English
:
Silent Information Regulator Proteins, Saccharomyces cerevisiae
History Note
English
:
2003
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
37322
Unique Identifier:
D037761
Occurrence in VHL
:
Similar:
DeCS