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DeCS
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Descriptor English:
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Securin
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Descriptor Spanish:
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Securina
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Descriptor Portuguese:
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Securina
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Synonyms English:
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PTTG Protein
Pituitary Tumor Transforming Proteins
Pituitary Tumor-Transforming Gene Protein
Pituitary Tumor-Transforming Proteins
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Tree Number:
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D12.776.167.504
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Definition English:
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Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation. |
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History Note English:
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2014
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Allowable Qualifiers English:
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Record Number:
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55328
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Unique Identifier:
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D064249
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Occurrence in VHL:
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Similar:
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DeCS
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