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Descriptor English:   Tolvaptan 
Descriptor Spanish:   Tolvaptán 
Descriptor Portuguese:   Tolvaptan 
Synonyms English:   7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
OPC 41061
OPC-41061
OPC41061
Samsca  
Tree Number:   D03.633.100.079.875
Definition English:   A benzazepine derivative and selective VASOPRESSIN V2 RECEPTOR antagonist that is used to treat euvolemic and hypervolemic HYPONATREMIA. It is also used in the treatment of rapidly progressing AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE to slow the rate of cyst development and renal insufficiency. 
Pharmacological Action:   Antidiuretic Hormone Receptor Antagonists
 
History Note English:   2019 (1999) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   57705 
Unique Identifier:   D000077602 

Occurrence in VHL:
 

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