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RYANODINE
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DeCS
Descriptor
English
:
Ryanodine
Descriptor
Spanish
:
Rianodina
Descriptor
Portuguese
:
Rianodina
Tree Number:
D02.455.849.291.686
D03.132.740
D03.383.129.578.805
Definition
English
:
A methylpyrrole-carboxylate from
RYANIA
that disrupts the
RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL
to modify
CALCIUM
release from
SARCOPLASMIC RETICULUM
resulting in alteration of
MUSCLE CONTRACTION
. It was previously used in
INSECTICIDES
. It is used experimentally in conjunction with
THAPSIGARGIN
and other inhibitors of
CALCIUM
ATPASE uptake of
calcium
into
SARCOPLASMIC RETICULUM.
History Note
English
:
91(75); was see under ALKALOIDS 1975-90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
12805
Unique Identifier:
D012433
Occurrence in VHL
:
Similar:
DeCS