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R38486
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DeCS
Descriptor
English
:
Mifepristone
Descriptor
Spanish
:
Mifepristona
Descriptor
Portuguese
:
Mifepristona
Synonyms
English
:
Mifegyne
Mifeprex
Mifégyne
R 38486
R-38486
R38486
RU 38486
RU 486
RU-38486
RU-486
RU38486
RU486
ZK 98296
ZK-98296
ZK98296
Tree Number:
D04.210.500.365.415.580
Definition
English
:
A progestational and glucocorticoid hormone antagonist. Its inhibition of
progesterone
induces bleeding during the
luteal phase
and in early
pregnancy
by releasing endogenous
prostaglandins
from the
endometrium
or
decidua
. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in
patients
with nonpituitary
CUSHING SYNDROME.
Pharmacological Action:
Abortifacient Agents, Steroidal
Contraceptives, Oral, Synthetic
Contraceptives, Postcoital, Synthetic
Hormone Antagonists
Luteolytic Agents
Menstruation-Inducing Agents
History Note
English
:
90
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
24783
Unique Identifier:
D015735
Occurrence in VHL
:
Similar:
DeCS