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QUINIDINE
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DeCS
Descriptor
English
:
Quinidine
Descriptor
Spanish
:
Quinidina
Descriptor
Portuguese
:
Quinidina
Synonyms
English
:
Adaquin
Apo Quinidine
Apo-Quinidine
Chinidin
Quincardine
Quinidex
Quinidine Sulfate
Quinora
Sulfate, Quinidine
Tree Number:
D03.132.206.636
D03.605.687.637
D03.633.100.810.699
Definition
English
:
An optical isomer of
quinine
, extracted from the bark of the CHINCHONA tree and
similar
plant species. This alkaloid dampens the excitability of cardiac and skeletal
muscles
by blocking
sodium
and
potassium
currents across cellular
membranes
. It prolongs cellular
ACTION POTENTIALS
, and decreases automaticity.
Quinidine
also blocks muscarinic and alpha-adrenergic neurotransmission.
Pharmacological Action:
Adrenergic alpha-Antagonists
Anti-Arrhythmia Agents
Antimalarials
Enzyme Inhibitors
Muscarinic Antagonists
Voltage-Gated Sodium Channel Blockers
Cytochrome P-450 CYP2D6 Inhibitors
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
12239
Unique Identifier:
D011802
Occurrence in VHL
:
Similar:
DeCS