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PLICAMYCIN
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DeCS
Descriptor
English
:
Plicamycin
Descriptor
Spanish
:
Plicamicina
Descriptor
Portuguese
:
Plicamicina
Synonyms
English
:
Aureolic Acid
Mithramycin
Mitramycin
Tree Number:
D02.455.426.559.847.562.050.650
D04.615.562.050.650
D09.408.051.059.650
Definition
English
:
A tricyclic pentaglycosidic antibiotic from
Streptomyces
strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors.
Plicamycin
is also used to reduce
hypercalcemia
, especially that due to malignancies.
Pharmacological Action:
Calcium-Regulating Hormones and Agents
Antibiotics, Antineoplastic
Fluorescent Dyes
Protein Synthesis Inhibitors
Nucleic Acid Synthesis Inhibitors
History Note
English
:
93; was MITHRAMYCIN 1971-92 (Prov 1971-72)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
30896
Unique Identifier:
D008926
Occurrence in VHL
:
Similar:
DeCS