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Descriptor English:   Placenta Growth Factor 
Descriptor Spanish:   Factor de Crecimiento Placentario 
Descriptor Portuguese:   Fator de Crescimento Placentário 
Synonyms English:   Factor, Placenta Growth
Growth Factor, Placenta
Placenta Growth Factor, PLGF 1 Isoform
Placenta Growth Factor, PLGF 2 Isoform
Placenta Growth Factor, PLGF 3 Isoform
Placenta Growth Factor, PLGF 4 Isoform
Placenta Growth Factor, PLGF-1 Isoform
Placenta Growth Factor, PLGF-2 Isoform
Placenta Growth Factor, PLGF-3 Isoform
Placenta Growth Factor, PLGF-4 Isoform  
Tree Number:   D12.644.276.100.800.100
Definition English:   An angiogenic protein belonging to the Vascular Endothelial Growth Factor family of growth factors originally isolated and cloned from human placental cDNA library. There are four isoforms of PLGF 1-4 which result from alternative splicing. Placenta Growth Factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer. 
History Note English:   2017 (1991) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   56528 
Unique Identifier:   D000072483 

Occurrence in VHL: