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PHLEOMYCINS
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DeCS
Descriptor
English
:
Phleomycins
Descriptor
Spanish
:
Fleomicinas
Descriptor
Portuguese
:
Fleomicinas
Synonyms
English
:
Phleomycin
Tree Number:
D09.400.420.110.710
D12.644.233.110.710
Definition
English
:
Water-soluble, copper-containing low
molecular weight
polypeptides
obtained from the
culture
medium of
Streptomyces
verticillus. They are specific inhibitors of DNA synthesis in
bacteria
and have been found to act as antitumor agents. They have also been used against rust fungi of
plants.
Pharmacological Action:
Antibiotics, Antineoplastic
Nucleic Acid Synthesis Inhibitors
History Note
English
:
91(81); was see under BLEOMYCINS 1981-90; was PHLEOMYCIN see under ANTIBIOTICS 1975-80
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
10886
Unique Identifier:
D010692
Occurrence in VHL
:
Similar:
DeCS