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PHENYLBARBITAL
Descriptors Found:
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DeCS
Descriptor
English
:
Phenobarbital
Descriptor
Spanish
:
Fenobarbital
Descriptor
Portuguese
:
Fenobarbital
Synonyms
English
:
Acid, Phenylethylbarbituric
Gardenal
Hysteps
Luminal
Monosodium Salt Phenobarbital
Phenemal
Phenobarbital Sodium
Phenobarbital, Monosodium Salt
Phenobarbitone
Phenylbarbital
Phenylethylbarbituric Acid
Sodium, Phenobarbital
Tree Number:
D03.383.742.698.253.650
Definition
English
:
A barbituric acid derivative that acts as a nonselective
central nervous system
depressant. It potentiates
GAMMA-AMINOBUTYRIC ACID
action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
Pharmacological Action:
Anticonvulsants
Hypnotics and Sedatives
Excitatory Amino Acid Antagonists
GABA Modulators
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP3A Inducers
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
10826
Unique Identifier:
D010634
Occurrence in VHL
:
Similar:
DeCS