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DeCS
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Descriptor English:
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Perforin
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Descriptor Spanish:
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Perforina
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Descriptor Portuguese:
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Perforina
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Synonyms English:
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Cytolysin
Lymphocyte Pore Forming Protein
Lymphocyte Pore-Forming Protein
Perforin 1
Pore-Forming Protein, Lymphocyte
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Tree Number:
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D12.776.543.695.875
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Definition English:
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A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell. |
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Pharmacological Action:
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Cytotoxins
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History Note English:
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2008
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Allowable Qualifiers English:
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Record Number:
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52798
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Unique Identifier:
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D054353
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Occurrence in VHL:
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Similar:
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DeCS
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