Search on: NEPRILYSIN 
Descriptors Found: 1
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Descriptor English:   Neprilysin 
Descriptor Spanish:   Neprilisina 
Descriptor Portuguese:   Neprilisina 
Synonyms English:   Antigen, CD10
Antigens, CD10
Antigens, Leukemia, Common Acute Lymphoblastic
Atriopeptidase
CALLA Antigen
CD10 Antigen
CD10 Antigens
Carboxypeptidase, Enkephalin Dipeptidyl
Common Acute Lymphoblastic Leukemia Antigens
Dipeptidyl Carboxypeptidase, Enkephalin
Endopeptidase 24.11
Endopeptidase 24.11, Neutral
Endopeptidase, Neutral
Endopeptidase-24.11
Enkephalin Dipeptidyl Carboxypeptidase
Enkephalinase
Enkephalinase 24.11
Enkephalinase-24.11
Enzyme, YGG-Forming
Kidney Brush Border Neutral Proteinase
Kidney-Brush-Border Neutral Proteinase
Membrane Metallo Endopeptidase
Membrane Metallo-Endopeptidase
Metallo-Endopeptidase, Membrane
Metalloendopeptidase, Thermolysin-Like
Neutral Endopeptidase
Neutral Endopeptidase 24.11
Neutral Proteinase, Kidney-Brush-Border
Thermolysin Like Metalloendopeptidase
Thermolysin-Like Metalloendopeptidase
YGG Forming Enzyme
YGG-Forming Enzyme  
Tree Number:   D08.811.277.656.300.480.600
D08.811.277.656.675.374.600
D23.050.285.550
D23.101.140.500
Definition English:   Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT. 
History Note English:   1997; was MEMBRANE METALLO-ENDOPEPTIDASE 1989-96; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS was COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGENS (NM) 1983-92 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   23757 
Unique Identifier:   D015260 

Occurrence in VHL:
 

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