Search on: NSILA-P 
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Descriptor English:   Nonsuppressible Insulin-Like Activity 
Descriptor Spanish:   Actividad Similar a la Insulina no Suprimible 
Descriptor Portuguese:   Atividade Insulin-Like não Suprimível 
Synonyms English:   Activity, Nonsuppressible Insulin-Like
Activity, Nonsuppressible Insulinlike
Insulin-Like Activity, Nonsuppressible
Insulinlike Activity, Nonsuppressible
NSILA
NSILA-P
NSILA-S
Nonsuppressible Insulin Like Activity
Nonsuppressible Insulinlike Activity  
Tree Number:   D12.776.124.862.575
Definition English:   A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity. 
Indexing Annotation English:   note category; a blood protein mimicking blood insulin
History Note English:   77 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   22249 
Unique Identifier:   D009632 

Occurrence in VHL:
 

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