Search on: N-(17-(2-(4-ISOPROPYLTHIAZOLE-2-YL)-7-METHOXY-8-METHYLQUINOLIN-4-YLOXY)-13-METHYL-2,14-DIOXO-3,13-DIAZATRICYCLO(13.3.0.04,6)OCTADEC-7-ENE-4-CARBONYL)(CYCLOPROPYL)SULFONAMIDE 
Descriptors Found: 1
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 1 / 1 DeCS     
Descriptor English:   Simeprevir 
Descriptor Spanish:   Simeprevir 
Descriptor Portuguese:   Simeprevir 
Synonyms English:   435, TMC
435350, TMC
N-(17-(2-(4-isopropylthiazole-2-yl)-7-methoxy-8-methylquinolin-4-yloxy)-13-methyl-2,14-dioxo-3,13-diazatricyclo(13.3.0.04,6)octadec-7-ene-4-carbonyl)(cyclopropyl)sulfonamide
Olysio
TMC 435
TMC 435350
TMC-435
TMC-435350
TMC435
TMC435350  
Tree Number:   D02.886.590.700.700
D03.633.300.819
Definition English:   Oral HCV-PROTEASE INHIBITOR effective against hepatitis C virus (HCV) serine protease NS3/4A. It is used in the treatment of chronic hepatitis C (Antivirals) genotype 1 infection in adults with compensated liver disease, including CIRRHOSIS. 
Pharmacological Action:   Antiviral Agents
Protease Inhibitors
 
History Note English:   2016 (2008) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   55903 
Unique Identifier:   D000069616 

Occurrence in VHL: 		 

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DeCS