Search on: MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS 
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Descriptor English:   Mitochondrial Transmembrane Permeability-Driven Necrosis 
Descriptor Spanish:   Necrosis por Permeabilidad de la Transmembrana Mitocondrial 
Descriptor Portuguese:   Necrose Dirigida por Permeabilidade Transmembrânica da Mitocôndria 
Synonyms English:   Mitochondrial Permeability Transition
Mitochondrial Transmembrane Permeability Driven Cell Death
Mitochondrial Transmembrane Permeability Driven Necrosis
Mitochondrial Transmembrane Permeability-Driven Cell Death  
Tree Number:   G04.146.954.393
Definition English:   A form of regulated cell death that is initiated by specific perturbations of the intracellular microenvironment such as severe OXIDATIVE STRESS and cytosolic CALCIUM overload, which result in osmotic breakdown of the MITOCHONDRIAL MEMBRANES. 
History Note English:   2020 
Allowable Qualifiers English:  
DE drug effects GE genetics
IM immunology PH physiology
RE radiation effects  
Record Number:   59157 
Unique Identifier:   D000079530 

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