Search on: MACROXYPROTEINASE 
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Descriptor English:   Proteasome Endopeptidase Complex 
Descriptor Spanish:   Complejo de la Endopetidasa Proteasomal 
Descriptor Portuguese:   Complexo de Endopeptidases do Proteassoma 
Synonyms English:   20S Proteasome
Complex, Multicatalytic Endopeptidase
Complex, Proteasome Endopeptidase
Endopeptidase Complex, Multicatalytic
Endopeptidase Complex, Proteasome
Ingensin
Macropain
Macroxyproteinase
Multicatalytic Endopeptidase Complex
Multicatalytic Proteinase
Prosome
Proteasome
Proteasome, 20S
Proteinase, Multicatalytic  
Tree Number:   D05.500.562.500
D08.811.277.656.918
D08.811.600.730
Definition English:   A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme. 
Entry Combination - descr/qualif English:   Proteasome Endopeptidase Complex/antagonists & inhibitors use Proteasome Inhibitors
 
See Related English:   Ubiquitin-Protein Ligase Complexes
 
History Note English:   2005; use PROTEASOME ENDOPEPTIDASE COMPLEX (NM) 1986-2004 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   38685 
Unique Identifier:   D046988 

Occurrence in VHL:
 

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