Search on: LOVASTATIN 
Descriptors Found: 1
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Descriptor English:   Lovastatin 
Descriptor Spanish:   Lovastatina 
Descriptor Portuguese:   Lovastatina 
Synonyms English:   1 alpha-Isomer Lovastatin
6 Methylcompactin
6-Methylcompactin
Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha Isomer
Lovastatin, 1 alpha-Isomer
MK 803
MK-803
MK803
Mevacor
Mevinolin
Monacolin K
alpha-Isomer Lovastatin, 1  
Tree Number:   D02.455.426.559.847.638.400
D04.615.638.400
Definition English:   A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. 
Pharmacological Action:   Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
 
History Note English:   88; for MONACOLIN K use LOVASTATIN (NM) 1980-98 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   22932 
Unique Identifier:   D008148 

Occurrence in VHL:
 

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DeCS